Monoclonal antibodies against tumor-associated antigens

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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5303871, 5303881, 435 7021, 4351722, 435 696, 4351723, 4352523, 4241551, 4241331, C12N 512, C07K 1630, A61K 39395

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056396210

ABSTRACT:
The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), to the preparation and use thereof and to the use of the epitope defined by the antibody for diagnosis and therapy.

REFERENCES:
Buchegger et al., "Monoclonal Antibodies Identify a CEA Crossreacting Antigen of 95 kD (NCA-95) Distinct in Antigenicity and Tissue Distribution From the Previously Described NCA of 55 kD", Int. J. Cancer, 33:643-649, (1984).
Bosslet et al., "Quantitative considerations supporting the irrelevance of of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas", Eur.J. Nucl. Med., 14:523-528 (1988).
Gussow et al., "Humanization of Monoclonal Antibodies", Methods in Enzymology, 203:99-121 (1991).
Saragovi et al., "Design and Synthesis of a Mimetic from an Antibody Complementarity-Determining Region", Science,253:792-795 (1991).
Tijssen, "The immobilization of immunoreactants on solid phases", Practice & Theory of Enzyme Immunoassays, pp. 297-328, (1984).
Kufe et al., "Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors", Hybridoma, 3(3): 223-232, (1984).
Burchell, et al., Cancer Research, vol. 47, pp. 5476-7482, Oct. 15, 1987.
Kabat et al., "Sequence of Proteins of Immunological Interest", 4th Ed., US Department of Health and Human Services, US Government Printing Office (1987).
Sambrook, Fritsch, Maniatis, "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Laboratory, pp. 11-44, 51-127, 133-134, 141, 146, 150-167, 170, 188-193, 197-199, 248-255, 270-294, 310-328, 364-401, 438-506 (1982).
Sambrook Fritsch, Maniatis, "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Press, pp. 16.20-16.22, 16.30-16.40, 16.54-16.55 (1989).
Wirth et al., "Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure", Gene 73: 419-426 (1988).
Hieter et al., "Evolution of Human Immunoglobulin k J Region Genes*", The Journal of Biological Chemistry, 257(3): 1516-1522 (1982).
Shimizu et al., "Isolation and Characterization of Mucin-Like Glycoprotein in Human Milk Fat Globule Membrane", J. Biochem., 91:515-524 (1982).
Girling et al., "A Core Protein Epitope of the Polymorphic Epithelial Mucin Detected by the Monoclonal Antibody SM-3 is selectively Exposed in a Range of Primary Carcinomas", Int. J. Cancer, 43:1072-1067 (1989).
Taylor-Papadimitriou et al., "Monoclonal Antibodies to Epithelium-Specific Components of the Human Milk Fat Globule Membrane: Production and Reaction with Cells in Culture", Int. J. Cancer, 28:17-21 (1981).
Gosling, "A Decade of Development in Immunoassay Methodology", Clin. Chem., 36(8):1408-1427 (1990).
Cordell et al.,"Immuoenzymatic Labeling of Monoclonal Antibodies Using Immune Complexes of Alkaline Phosphatase and Monoclonal Anti-alkaline Phosphatas (APAAP Complexes)", Journal of Histochemistry and Cytochemistry, 32(2):219-229 (1984).
Orlandi et al., "Cloning immunoglobulin variable domains for expression by the polymerase chain reaction", Proc.Nat.Acad.Sci.USA, 86:3833-3837(1989).
Sanger et al., "DNA sequencing with chain-terminating inhibitors", Proc. Natl. Acad. Sci. USA, 74(12):5463-5467 (1977).
Miller et al., "Monoclonal Antibody Therapeutic Trials in Seven Patients With T-Cell Lymphoma", Blood, 62(5):988-995 (1983).
Joseph et al., "In vivo labelling of granulocytes with .sup.99m Tc anti-NCA monoclonal anti-bodies for imaging inflammation", Eur. J. Nucl. Med., 14:367-373 (1988).
Jones et al., "Replacing the complementarity-determining regions in a human antibody with those from a mouse", Nature, 321:522-525 (1986).
Reichmann et al., "Reshaping human antibodies for therapy", Nature, 332:323-327 (1988).
Verhoeyen et al., "Reshaping Human Antibodies: Grafting an Antilysozyme Activity", Science, 239:1534-1536 (1988).
Hanisch et al., "Monoclonal Antibody BW385 Defines a Site-specific Thomsen-Friedenreich Disaccharide Linked to Threonine within the VTSA Motif of MUC1Tandem Repeats", Cancer Research, 55:4036-4040, (Sep. 1995).
Seaver et al 1994 Genetic Engineering vol. 14(14) pp. 10 +12.
Burchell et al 1989 Int. J. Cancer vol. 44:691-696.
Layton et al 1990 Tumor Biology vol 11:274-286.
Burchell et al Cancer Research 1987 vol. 47:5476-5482.
Paul, W.E. 1993 Fundamental Immunology p. 242.

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