Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-05-14
1999-03-30
Eisenschenk, Frank C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435337, 435217, 53038825, 5303893, 5303911, 5303913, 436518, 436 69, 436548, G01N 3353, C07K 1636
Patent
active
058887539
ABSTRACT:
The invention relates to monoclonal antibodies (MAbs) and fragments thereof which have a specific affinity for the plasmin-antiplasmin complex and which display no affinity or only a very low affinity for the individual components of these complexes, and to antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic aid, active substance or active substance carrier.
REFERENCES:
patent: 4216291 (1980-08-01), Collen
Paul Holvoet et al, An Enzyme-Linked Immunosorbent Assay (ELISA) for the Measurement of Plasmin-.alpha.2 -Antiplasmin Complex in Human Plasma-Application to the Detection of In Vivo Activation of the Fibrinolytic System; Thrombosis and Haemostasis 56, pp. 124-127 (1986).
Jun Mimuro et al, Monoclonal Antibodies to Discrete Regions in Plasmin Inhibitor; Blood, vol. 69, No. 2, pp. 446-453 (1987).
G. Koehler et al, Continuous cultures of fused cells secreting antibody of predefined specificity; Nature, vol. 256, pp. 495-497 (1975).
Monoclonal Antibodies, Appendix pp. 363-374 Kennett,R.et.al., eds. Plenum Press, 1980.
Melchers, F., Potter, M. and Warner, N., Current Topics in Microbiology and Immunology, Preface vol. 81, Springer Verlag (1978).
Harpel, J. Clin. Invest., 68:46-55 (1981).
Harlow et al ed. 1988 Antibodies A Laboratory Manual, Cold Spring Harbor Laboratory pp. 555,556,558,561,612.
Harlow et al Antibodies, A Laboratory Manual , 1988 Cold Spring Harbor Laboratory pp. 141-142.
Proceedings of the National Academy of Sciences of USA, 8d. 87, Feb. 1990; Reed et al.; Synergistic Fibrinolysis: Combined Effects of Plasminogen Activators and an Antibody that Inhibits Alpha 2-Antiplasmin. pp. 1114-1118.
Hock Johann
Pelzer Hermann
Behring Diagnostics GmbH
Eisenschenk Frank C.
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