Monoclonal antibodies against prosumal proteins

Details Monoclonal antibodies against prosumal proteins Monoclonal antibodies against prosumal proteins

1989-01-17

1991-10-22

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 723, 4351722, 43524027, 435810, 435960, 436501, 436503, 436536, 436548, 436 64, 436808, 436813, 530387, 530808, 935 95, 935103, 935106, 935110, G01N 3353, G01N 33577, G12N 1500, C07K 1514

Patent

active

050595210

ABSTRACT:
The invention relates to monoclonal antibodies against prosomal proteins of a prosome, said prosome having a sedimentation coefficient of approximately 19S, and to a method for detecting cancer using monoclonal antibodies specifically directed against said prosomal proteins. The invention also relates to diagnostic reagents for use in such a detection method.

REFERENCES:
patent: 4444744 (1984-07-01), Goldenberg
patent: 4448890 (1984-05-01), Smetana et al.
Chemical Abstract, Pisetsky et al., vol. 101, Abst. No. 53111x, 1984.
Schmid et al., The EMBO Journal, vol. 3, No. 1, 1984, pp. 29-34.
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Choi et al., Proc. Natl. Acad. Sci., U.S.A., vol. 81, Dec. 1984, pp. 7471-7475.
Sevier et al., Clin. Chem., vol. 27(11), 1981, pp. 1797-1806.
Schuldt et al., "Analysis of Cytoplasmic 19 S Ring-Type Particles in Drosophilia which Contain hsp 23 at Normal Growth Temperature," Dev. Biol., 110(1), 65-74 (Jul. 1985).
Martins de Sa et al., "Prosomes and the Heat-Shock Complex," Molecular and Cellular Biology, vol. 9, pp. 2672-2661 (1989).
Naraya et al., "Minute Ring-Shaped Particles in Cultured Cells of Malignant Origin", Nature New Biology, (243) 146-150 (1973).
Domae et al., "Donut Shaped `Miniparticles` in Nuclei of Human and Rat Cells," Life Sciences, (30), 469-477 (1982).
Arrigo et al., "Characterization of the Prosome from Drosophilia and its Similarity to the Cytoplasmic Structures Formed by the Low Molecular Weight Heat-Shock Proteins," The EMBO Journal, 4(2) 399-406 (Feb. 1985).

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