Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-01-11
2011-01-11
Haq, Shafiqul (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007920, C435S007940, C435S070210, C435S336000, C435S344000, C436S518000, C436S548000, C436S064000, C530S388240, C530S388800, C530S388850, C530S389100, C530S389200, C530S389700, C530S391100
Reexamination Certificate
active
07867725
ABSTRACT:
The present invention relates to reagents and methods for the detection of osteopontin fragments and distinguishing them from each other and from the full-length osteopontin protein. The present invention also relates to assays for the determination of the presence of osteopontin fragments in samples obtained from subjects and, further, the correlation of osteopontin fragment levels fragment levels with disease detection, progression and prognosis.
REFERENCES:
patent: 6414219 (2002-07-01), Denhardt et al.
patent: 2005/0009120 (2005-01-01), Mok et al.
Kon et al., 2000. Antibodies to different peptides in osteopontin reveal complexities in the various secreted forms. J. Cellular Biochem. 77: 487-498.
Kon et al., 2002. Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. J. Cellular Biochem. 84: 420-432.
Hotta et al., 1999. Detection of various epitopes of murine osteopontin by monoclonal antibodies. Biochem. Biophys. Research Comm. 257: 6-11.
Agnihotri et al., 2001. Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J. Biol. Chem. 276: 28261-28267.
Rudland, et al., Cancer Res, 62(12):3417-3427, 2002.
Fedarko, et al., Clin Cancer Res 7(12):4060-4066, 2001.
Gao, Y.A., et al., Matix Biol, 23(7):457-466, 2004.
Senger, D.R., et al., Ann NY Acd Sci, 760:83-100, 1995.
Senger, D.R., et al., Am J Pathol, 149(1):293-305, 1996.
Senger D.R., et al., Biochem Biophys Acta, 1314(1-2):13-24, 1996.
Bayless, K.J., et al., J Biol Chem, 276(16):13483-13489, 2001.
Green, P.M., et al., FEBS Lett, 503(1):75-79, 2001.
Smith, L.L., et al., Exp Cell Res, 242:351-360, 1998.
Yokosaki, Y., et al., Matrix Biol, 24(6):418-427, 2005.
Vordermark, et al, “Plasma osteopontin levels in patients with head and neck cancer and cervix cancer are critically dependent on the choice of ELISA system” BMC Cancer, 6(1):207, 2006.
Engvall, Eva, et al., Enzyme-linked immunosorbent assay. II. Quantitative assay of protein antigen, immunoglobulin G, by means of enzyme-labelled antigen and antibody-coated tubes. Biochim Biophys Acta, 251(3):427-434, 1971.
Kohler, G. and Milstein, C., Nature, 256(5517):495-7 1975.
Mark, et al., J Histochem Cytochem, 35(7):707-716, 1987.
Mark, M.P., et al., Cell Tissue Res, 251:23-30, 1988.
Liaw, et al., Circ Res, 74(2):214-24 1994.
Liaw, et al., J Clin Invest, 101(7):1468-78 1998.
Liaw Lucy
Ng Ah-Kau
Farrell Kevin M.
Grun James L
Haq Shafiqul
Maine Medical Center
Pierce Atwood LLP
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