Monoclonal antibodies against non small cell lung cancer

Details Monoclonal antibodies against non small cell lung cancer Monoclonal antibodies against non small cell lung cancer

1983-05-18

1986-02-11

Nucker, Christine M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

436513, 436548, 436804, 436808, 436813, 435 4, 435 7, 435 29, 435 68, 4351722, 435810, 435948, 935110, C12N 1500, G01N 3354

Patent

active

045697884

ABSTRACT:
Monoclonal antibodies 703D4 and 704A1 detect human non-small cell lung cancer (non-SCLC) and distinguish non-SCLC from all other types of lung cancer and normal tissue cells. These two antibodies may be utilized in kit form to distinguish non-SCLC from other forms of lung cancer. These monoclonal antibodies bind to S.sup.35 methionine-incorporating protein doublets under reduced and unreduced conditions. The determinants bound by these antibodies on the 31 kiladalton protein are independent of each other as determined in radiolabelled competition assays.

REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4317877 (1982-03-01), Balis et al.
patent: 4331647 (1982-05-01), Goldenberg
patent: 4349528 (1982-09-01), Koprowski et al.
patent: 4361544 (1982-11-01), Goldenberg
Mulshine, J. L. et al, J. of Immunology, vol. 131 (1), pp. 497-502 (7-1983).
Gazdar, A. F. et al, Seminars in Oncology, vol. 10 (1), pp. 3-19 (3-1983).
Carney, D. N. et al, Pathobiol Annual, vol. 12, pp. 115-136 (1982).
Baylin, S. B. et al, Proc. Natl. Acad, Sci, USA, vol. 79, pp. 4650-4654 (8-1982).
Cuttitta et al; PNAS, vol. 78, pp. 4591-4595 (1981).
Kohler et al; Nature, vol. 256, pp. 495-497 (1975).
Moody, T. W. et al, Science, vol. 214, pp. 1246-1248 (12-1981).
Brown, J. P. et al, Clinical Chemistry, vol. 27, pp. 1592-1595 (1981).
Minna et al, In Vitro , vol. 17, pp. 1058-1070 (1981).

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