Monoclonal antibodies against metal chelates

Details Monoclonal antibodies against metal chelates Monoclonal antibodies against metal chelates

1984-08-31

1988-02-02

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 85, 436 73, 436 81, 436548, 436813, 530387, 530808, 935110, G01N 33577

Patent

active

047228920

ABSTRACT:
Monoclonal Antibodies which are specific for a complex of a chelating agent and a metallic ion are described. The antibody has an association constant (K.sub.a) for the complex which is at least about ten times greater than the K.sub.a for the chelating agent alone or its complex with another metal.

REFERENCES:
patent: 4472509 (1984-09-01), Gansow
patent: 4474893 (1984-10-01), Reading
Scheinberg, D. A. et al., Science, 215 (4539), 1511-1513 (Mar. 19, 1982).
Chemical Abstracts, 100:205818c (1984).
Buckley, R. G. et al., Febs Letters, 166 (1) 202-204 (Jan. 23, 1984).
Powe, J. et al., Cancer Drug Delivery, 1(2), 125-135 (1984).

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