Monoclonal antibodies against lens epithelial cells and preventi

Details Monoclonal antibodies against lens epithelial cells and preventi Monoclonal antibodies against lens epithelial cells and preventi

1982-03-05

1984-02-21

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

128 1R, A61B 1900

Patent

active

044327510

ABSTRACT:
Disclosed are monoclonal antibodies against lens epithelial cells and methods of producing them. Continuous cell lines for producing monoclonal antibodies to lens epithelial cells are disclosed. Human lens epithelial antibody producing cells are fused with myeloma cells to provide a fused hybrid, the hybrid is cultured, and antibodies specific to human lens epithelial cells are collected.
Proliferation of remnant lens epithelial cells after extracapsular extraction is prevented by instilling the monoclonal antibodies specific to lens epithelial cells into the anterior chamber of the human eye and allowed to interact with the lens epithelial cells. Complement is then instilled into the anterior chamber to cause lysis or other damage to the lens epithelial cells thereby preventing them from multiplying and migrating to cover the surface of the lens capsule left in place. This can be done at the time of extracapsular cataract extraction or later to remove a second cataract caused by proliferation of these cells. There is no damage to other parts of the eye, but only to the remnant lens epithelial cells.

REFERENCES:
patent: 4307082 (1981-12-01), Rosenberg
patent: 4342828 (1982-08-01), Takaku et al.
patent: 4349528 (1982-09-01), Koprowski et al.

Affiliated with

Also associated with

Rating

Monoclonal antibodies against lens epithelial cells and preventi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibodies against lens epithelial cells and preventi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies against lens epithelial cells and preventi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1033717