Monoclonal antibodies against lens epithelial cells and methods

Details Monoclonal antibodies against lens epithelial cells and methods Monoclonal antibodies against lens epithelial cells and methods

1988-06-14

1993-04-13

Lacey, David L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

5303882, 5303913, 5303911, C12N 512, C07K 1528

Patent

active

052022528

ABSTRACT:
Compositions and methods for their use are provided for preventing proliferation of remnant lens epithelial cells following extracapsular extraction. Complement-fixing monoclonal antibodies specific for lens epithelial cells are introduced into the anterior chamber of the eye. Following binding of the monoclonal antibody to any lens epithelial cells, complement is introduced into the anterior chamber effecting lysis of the remnant lens epithelial cells. The method may be used at the time of extracapsular cataract extraction or may be used subsequently to remove a second cataract resulting from proliferation of remnant lens epithelial cells.

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patent: 4590071 (1986-05-01), Scannon et al.
patent: 4698420 (1987-10-01), Urnovitz
Samuel Fulcher, et al. "Use of Immunotoxin to Inhibit Proliferating Human Corneal Endothelium," Investigative Opthalmology & Visual Science, vol. 29, May, 1988, pp. 755-759.
Thomas J. Hansen, et al., "Methotrexate-Anticollagen Conjugate Inhibits In Vitro Lens Cell Outgrowth," Investigative Opthalmology & Visual Science, vol. 28, Jul., 1987, pp. 1206-1209.
Zam, Z. S., et al, Cancer Eye Research, 1(3):139-144 (1981).
Carper, D. et al., Developmental Biology, 113:104-109 (1986).

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