Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-06-08
1990-07-10
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
43524027, 435948, 435 7021, 436513, 424 858, 530809, 935104, 935107, C12N 520, C07K 1528, A61K 3900
Patent
active
049407821
ABSTRACT:
The present invention is directed to monoclonal antibodies and hybridomas which produce them, which react with IgE when it is unbound and thereby inhibit IgE binding to mast cells, and react with IgE when it is bound to the B-cell FcE receptor, but do not react with IgE when it is bound to the mast cell FcE receptor.
REFERENCES:
Conrad, D. H. et al., "Properties of Two Monoclonal Antibodies Directed Against the Fc and Fab' Regions of Rat IgE," Int. Arch. Allergy Appl. Immunol. 70:352-360, 1983.
Stanworth, D. R. et al., "Anti-E-Chain Antibodies as Probes in the Study of Mast-Cell Triggering," Molec Immunol. 23(11): 1231-1235, 1986.
Mouse Monoclonal Antibody to Rat Epsilon Heavy Chain, Serotec, Code No.: MCA 193.
Kahn Larry E.
Rup Bonita J.
Cheney Kay E.
G. D. Searle & Co.
Kanady Mary Jo
Matukaitis Paul D.
Moskowitz Margaret
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