Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-12-28
1996-12-10
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 794, 435 7021, 43524027, 436811, 436815, 5303881, G01N 3353, G01N 33537, C07K 1618
Patent
active
055829988
ABSTRACT:
The invention concerns monoclonal antibodies, designated tbp-1, tbp-2 and tbp-6, against the extracellular part of the human 60 kD TN tumour necrosis factor receptor (TNF-BP I). These antibodies are suitable for use in highly sensitive immuno-assays for demonstrating the presence of TNF-BP I in body fluids, including urine, and in cell-culture residues. The determination of the TNF-BP I concentration as the basis for a diagnosis of pathological conditions associated with activation of the TNF receptor system is thus particularly useful if the .alpha.-TNF concentration in the organism falls more rapidly than the TNF-BP I concentration. In addition, tbp-1 and tbp-6 can be used to strengthen the protective action of TNF-BP I against .alpha.-TNF and/or .beta.-TNF.
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Boehringer Ingelheim International GmbH
Duffy Patricia A.
Hutzell Paula K.
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