Monoclonal antibodies against human colon carcinoma-associated a

Details Monoclonal antibodies against human colon carcinoma-associated a Monoclonal antibodies against human colon carcinoma-associated a

1994-09-12

1997-11-18

Loring, Susan A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 435 4051, 435 4052, 435325, 435328, 435329, 435330, 435332, 435344, 5303888, 5303871, 5303873, 5303875, 5303877, 5303881, 5303911, 5303913, 5303917, G01N 33574, G01N 3353, C07K 1630, C07K 1618

Patent

active

056886578

ABSTRACT:
Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/human chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fragments and derivatives thereof, are useful in immunodiagnosis and immunotherapy of human colon, breast, and ovarian cancer, and for purification of antigens which can serve as immunotherapeutic agents. Methods of detecting the colon carcinoma-associated antigen in a sample, and methods for treating subjects having colon, breast, and ovarian carcinomas are disclosed.

REFERENCES:
patent: 4579827 (1986-04-01), Sakamoto et al.
patent: 4699880 (1987-10-01), Goldstein
patent: 4810781 (1989-03-01), Hollinshead
Bartal, A. H et al, Proc. Am Assoc. Can Res, 31:260 (Ast#1537), Mar. 1990.
Price, M.R et al, IRCS J Med Sci, 13(4):366-367, Apr. 1985.
Herlyn, M et al, PNAS, 76(3):1438-1442, Mar. 1979.
Tsang, K.Y. et al, Fed Proc, 46(3):1058 (Abst#4322), Mar. 1987.
Xu, Danlin, Dissertation (Degree 1990) order #9109383, pp. 1-86, 1990.
Kanellos, J et al, JNCI, 75(2):319-332, Aug. 1985.
Shaw, D.R et al, J Immunol, 138:4534-4538, Jun. 15, 1987.
Tsang, K.Y et al, FASEB, J2(5):A6815, 1988.
Hollinshead, A., et al., Science, 177: 887-889 (1972).
Von Kleist, S., et al., Proc. Natl. Acad. Sci. USA 69: 2492-2494 (1972).
Hollinshead, A.C., J. Nat. Cancer Instit. 52: 327-338 (1974).
Hollinshead, A.C., Cancer, 34: 1235-1243 (1974).
Hollinshead, A.C., Lung Cancer Progress in Therapeutic Research, pp. 501-520, Muggia, F., Rosencweig, M. (ed.), Raven Press (1979).
Herlyn, M., et al. Proc. Natl. Acad. Sci. USA 79: 1438-1442 (1979).
Hollinshead, A. et al., Tumor Progression, pp. 289-300, Crispen (ed) (1980).
Herlyn, M., et al. J. Clinical Immunol. 2: 135-140 (1982).
Hollinshead, A.C., et al., Cancer 49: 1387-1404 (1982).
Moldofsky, P.J., et al., Radiology 149: 549-555 (1983).
Buchegger, F., et al., J. Experimental Medicine 158: 413-427 (1983).
Takita, J., et al., Cancer Immunol. Immunother. 20: 231-235 (1985).
Price, M.R., et al., IRCS Med. Sci. 13: 366-367 (1985).
Kanellos, J., et al., JNCI 75: 319-332 (1985).
Hollinshead, A., et al., Cancer 56: 480-489 (1985).
Stewart, T.H.M., et al., Lung Cancer: Current Status and Prospects for the Future-Ann. Clin. Conf. on Cancer 28: 351-374 (1986).
Tsang, K., et al., JNIC 77: 1175-1180 (1986).
Douillard, J.Y., et al., Hybridoma 5: 5139-5149 (1986).
Hollinshead, A., Biologic Drugs, Vaccines: Current Status and Future Directions, pp. 85-103, Springer Verlag (1986).
Greiner, J.W., et al., Science 235: 895-898 (1987).
Tsang, K., et al., Fed Proc. 46:4322 (1987).
Shaw, D.R., et al., J. Immunology 138: 4532-4538 (1987).
Tsang, K., et al., Cancer Detection and Prevention 11: 094 (1987).
Tsang, K., et al., Fed. Proc. 6815 (1988).
Tsang, K., et al., 7th International Congress of Immunology, Abstract 125-46 (1989).
Bartel, A., et al., Proceedings 31: Abstract 1537 (1990).
Arlen, M. and Tsang, K., J. Tumor Marker Oncology 5: 313-319 (1990).
Hirschfield, L.S., et al., Federation of American Societies for Experimental Biology, Absract 5708 (1991).
Xu, D.L., et al., Fed. Amer. Soc. Exper. Biol., Abstract 2109 (1991).
Hollinshead, A.C. and Stewart, T.H.M., Yale Journal of Biology and Medicine 54: 367-379 (1981).
Sears, H.F., et al., J. Clinical Immunol. 2: 141-149 (1982).
Arlen, M., et al., Antibody, Immunoconjugates, and Radiopharmaceuticals, 4: 895-905 (1991).
Arlen, M., et al., Journal of Surgical Oncology 54: 103-108 (1991).
Arlen, M., et al., NY Academy (cancer vaccines) 603-605 (1993).
Fernado, A.D. et al., Miami Symp. Short Reports 3: 88 (1993).
Girardet, C., et al., J. Immunology 136: 1497-1503 (1986).

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