Monoclonal antibodies against human apoptosis inhibitory...

Details Monoclonal antibodies against human apoptosis inhibitory... Monoclonal antibodies against human apoptosis inhibitory...

2006-11-28

2006-11-28

Yu, Misook (Department: 1642)

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

C436S518000

Reexamination Certificate

active

07141435

ABSTRACT:
An anti-NAIP monoclonal antibody recognizing a human apoptosis inhibitory protein NAIP having the amino acid sequence of SEQ ID NO: 1, which is produced from hybridoma prepared by fusing a myeloma cell line with antibody-producing cell of mammal immunized by antigen containing a polypeptide which comprises amino acid sequence of the 256–586th, the 841–1052nd or parts thereof in SEQ ID NO: 1, NAIP assay method using the antibody, and NAIP assay kits.

REFERENCES:
patent: 97/26331 (1997-07-01), None
Harlow et al (1988, Antibodies A Laboratory Manual, Cold Spring Harbor Laboratory, pp. 556, 558, 579-581 only).
Biological Abstracts, No. 199799598887, D. G. Xu et al., “Distribution of Neuronal Apoptosis Inhibitory Protein-Like Immunoreactivity in the Rat Central Nervous System”, & Journal of Comparative Neurology, 1997, vol. 382, No. 2, pp. 247-259.
Natalle Roy et al., “The Gene for Neuronal Apoptosis Inhibitory Protein is Partially Deleted in Individuals with Spinal Muscular Atrophy”, Cell, 1995, vol. 80, No. 1, pp. 167-178.
Ikeda et al., “Neuronal apoptosis inhibitory protein NAIP and its related nerve degenerate disorder”,Journal of Nippon Medical School,vol. 64, No. 5, pp. 471-474, 1997.
Chen et al., “Sequence of a 131-kb Region of 5q 13.1 Containing the Spinal Muscular Atrophy Candidate Genes SMN and NAIP”,Genomics,vol. 48, pp. 121-127, 1998.

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