Monoclonal antibodies against hepatitis B virus

Details Monoclonal antibodies against hepatitis B virus Monoclonal antibodies against hepatitis B virus

1990-07-17

1993-04-20

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 435 7021, 4351722, 43524027, 435 5, 435 79, 436518, 436548, 436531, 436820, 5303883, A61K 3942, A61K 3944

Patent

active

052040950

ABSTRACT:
The new hybridoma cell lines RF-HBs-1, RF-HBs-2 and RF-HBs-4 each secrete a nonoclonal antibody to hepatitis B surface antigen. The production of the antibodies may be carried out in vitro by culturing one of the cell lines or in vivo by establishing one of the cell lines as an ascites tumour in a mouse and isolating antibodies from the ascites fluid or from the serum. The antibodies have therapeutic, preventative and diagnostic uses in respect of hepatitis B virus infections and can be used to purify hepatitis B surface antigen. The relative specificities of the three monoclonal antibodies make them particularly useful in radiometric assay techniques employing specific combinations of the antibodies in solid phase.

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"The Production of a Monoclonal Antibody to HBs Antigen and its use in the Detection and Immunopathology of Hepatitis B Virus Infection" (1980) Goodall et al. (Paris) Abstract 19.2.09.
Transfusion (Philadelphia) 19 No. 5, p. 637 (Sep./Oct. 1979) Shih et al "Production of Monoclonal Antibodies Against Hepatitis B Surface Antigen by Somatic Cell Hybrids".
Gastroenterology 77 No. 5 P.A46 (1979) Wands et al "Production and characterisation of Monoclonal Antibodies to Hepatitis B surface antigen (HBsAg) by cellular hybridisation".
Federation Proceedings 39 No. 3, p. 929, point 3484 (Mar. 1, 1980) Present et al "Characterization of murine hybridoma antibodies to Hepatitis B surface antigenic determinants".
Gastroenterology 79, No. 5 p. 1063 (part 2, Nov. 1980) Wands et al "Immunodiagnosis of Hepatitis B by high affinity monoclonal anti-HB antibodies".
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