Monoclonal antibodies against GnRH

Drug – bio-affecting and body treating compositions – Lymphokine

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435240, 435 68, 4351722, 935104, 935107, 530387, A61K 39395, C12N 500, C12N 1500, C12P 2100

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active

046769811

ABSTRACT:
A monoclonal antibody against GnRH and particularly designated USASK/DSIL-GnRH is produced by a hybrid formed by fusion of cells from a myeloma line and antibody producing cells of the immune system from an animal previously immunized with a source of GnRH; the monoclonal antibody has the following characteristics:

REFERENCES:
Knapp et al., "High Affinity Monoclonal Antibodies to Luteinizing Hormone--Releasing Hormone", J. of Neuroimmunology, 6 (1984) 361-371.
Talwar et al., "New Approaches for Contraceptive Vaccine", Second International Conference on Immunopharmacology, (ed. Hadden) Pergamon Press (conf. Jun. 1983).
Siddle et al., "Monoclonal Antibodies for Human Pituitary Glycoprotein Hormones and Rabbit Immunoglobulin", Monoclonal Antibodies and Develop. in Immunoassays, pp. 53-66, (1981).
Shastri et al., "Important Role of the Carrier in the Induction of Antibody Response w/out Freund's Complete Adjuvant Against a Self Peptide LHRH", Am. J. Reprod. Imm., 1:262-65, (1981).
McCormack et al., "The Effect of LHRH Antiserum Administ. on Gonadotropin Secretion in the Rhesus Monkey", Endocrinology 100: 663-667, (1977).
Lincoln et al., "Antler Growth in Male Red Deer (Cervus elaphus) After Active Immunization Against LHRH", J. Reprod. Fert., (1982), 66, pp. 703-708.
Knapp et al., "Heterogeneity of Luteinizing Hormone Releasing Hormone--Immunoreactivity Studied Using a Monoclonal Antibody".
13th Annual Meeting of the Society for Neuroscience, Nov. 6-11, 1983, p. 183, Abst. #40.3.
Persson, L., Aeta Chem. Scand. B, 35:737-738, (1981).
Kameji, T. et al., Biochem. Biophys. Acta, 717:111-117, (1982).

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