Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-08-06
1993-01-26
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435968, 435 725, 436 64, 436813, 424 11, 424 9, 5303913, G01N 33574, A61K 4900
Patent
active
051821923
ABSTRACT:
The present invention is directed to in vitro and in vivo immunodiagnosis and immunotherapy using monoclonal antibodies reactive with difucosyl blood group antigens Y-6 and B-7-2.
REFERENCES:
patent: 4522918 (1985-06-01), Schlom et al.
patent: 4612282 (1986-09-01), Schlom et al.
patent: 4675287 (1987-06-01), Reisfeld et al.
patent: 4714613 (1987-12-01), Shouval et al.
patent: 4731244 (1988-03-01), Talle et al.
patent: 4737579 (1988-04-01), Hellstrom et al.
patent: 4739279 (1988-03-01), Stephan et al.
Steplewski et al, "Isolation and Characterization of Anti-Monosialoganglioside Monoclonal Antibody 19-9 Class-Switch Variants" Proc. Natl. Acad. Sci. U.S.A. 82:8653-8657 (Dec. 1985).
McKibbon, et al., J. Biol. Chem., vol. 257, pp. 755-760, 1982.
Hansson, et al., J. Biol. Chem., vol. 258, pp. 4091-4097, 1983.
Breimer, et al., Biomedical Mass Spectrometry, vol. 6, No. 6, pp. 231-241.
"Monoclonal Antibodies Specific Immunotherapy of Gastrointestinal Tumors" Douillard, Lehur, Vignoud, Blottiere, Maurel, Thedrez, Kremer and Mevel, Hybridoma vol. 5, Suppl. I, 1986.
"Effector Cells in ADCC With Anti-Breast Cancer Monoclonal Antibodies in: Monoclonal Antibodies and Breast Cancer", Steplewski, Blaszczyk, Herlyn, Herlyn & Koprowski, ed. Ceriani, published by Nijhoff Publishers, N.Y., 1985.
"Differential Expression of Difucosyl Type 2 Chain (Le.sup.Y) Defined by Monoclonal Antibody AH6 in Different Locations of Colonic Epithelia, Various Histological Types of Colonic Polyps, and Adenocarcinomas", Abe, Hakomori & Ohshiba [Cancer Research, 46, 2639-2644, May, 1989).
"Quantitative and Qualitative Characterization of Human Cancer-associated Serum Glycoprotein Antigens Expressing Fucosyl or Sailyl-Focosyl Type 2 Chain", Kannagi, Fukushi, Tachikawa, Noda, Shin, Shigeta, Hiraiwa, Fukuda, Inamoto, Hakamori, Imura., Cancer Research 46, 2619-2626, 1986.
"A Spectrum of Monoclonal Antibodies Reactive With Human Mammary Tumor Cells", Colcher, Hand, Nuti & Schlom, Proc. Nat'l Acad. Sci., U.S.A., vol. 78, No. 5, pp. 3199-3203, May 1981 Medical Sciences.
"Monoclonal Antibody (B72.3) Defines Patterns of Distribution of a Novel Tumor-Associated Antigen in Human Mammary Carcinoma Cell Populations", Nuti, Teramoto, Mariani-Costantini, Hand Colcher & Schlom, J. Cancer: 29, 539-545.
Sears, et al., The Lancet, Apr. 3, 1981, pp. 762-765 (1982) "Phase-I Clinical Trial of Monoclonal Antibody in Treatment of Gastrointestinal Tumors".
Carrasquillo, et al., Cancer Treat. Rep., 68:317-328 (1984), "Diagnosis of and Therapy for Solid Tumors With Radiolabeled Antibodies and Immune Fragments".
Sears, et al., Cancer Res., 45:5910-5913 (1985), "Phase II Clinical Trial of a Murine Monoclonal Antibody Cytotoxic for Gastrointestinal Adenocarcinoma".
Steplewski, et al., Hybridoma, 5:S59-S64 (1986), "Mechanisms of Tumor Growth Inhibition".
Abe, et al., J. Biol. Chem. 258-11793-11797 (1983), "The Monoclonal Antibody Directed to Difucosylated Type 2 Chain (Fucal-2-Gal-B1-4 [Fucal-3] GlcNAc; Y Determinant)".
Brown, et al., Biosci. Rep., 3:163-70 (1983), "A Monoclonal Antibody Against Human Colonic Adenoma Recognizes Difucosylated Type-2-Blood-Group Chains".
Lloyd, et al., Immunogenetics. 17:537-541 (1983), "Mouse Monoclonal Antibody F-3 Recognizes the Difucosyl Type-2 Blood Group Structure".
Bundle, et al., J. Immunol.
Koprowski Hilary
Steplewski Zenon
Thurin Magdalena
Bidwell Carol E.
Kepplinger Esther L.
The Wistar Institute
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