Monoclonal antibodies against c-kit and method of detecting a ma

Details Monoclonal antibodies against c-kit and method of detecting a ma Monoclonal antibodies against c-kit and method of detecting a ma

1995-06-06

1996-08-13

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

43524027, 435 7021, 5303877, 53038885, 5303887, 53038873, G01N 3353, C07K 1632, C12N 520

Patent

active

055455336

ABSTRACT:
The invention concerns monoclonal antibodies against the human c-kit receptor which are obtainable from the cell lines DSM ACC 2007, DSM ACC 2008 and DSM ACC 2009 or are capable of binding to the c-kit receptor in an equivalent manner to the antibodies produced by the cell lines DSM ACC 2007, DSM ACC 2008 or DSM ACC 2009. The present invention also concerns a method for testing the malignancy of tumours of haematopoietic cells, of seminomas or small-celled lung carcinoma in which a tissue sample is incubated with at least one monoclonal antibody against the c-kit receptor according to the present invention and subsequently bound antibodies are detected by means of known methods.

REFERENCES:
Waldmann, Science 252:1657-1662, 1991.
Harris et al., Tibtech 11:42-44, 1993.
Lerner et al., Blood 77:1876-1883, 01 May 1991.
Broudy et al. Blood 79(2):338-346, 1992 (15 Jan.)
Gadd et al. Leukemia Research 9:1329-1336, 1985.
Buhring et al. Cancer Res 53:4424-31 15 Sep. 1993.
Buhring et al. Leukemia 5:854-859, 1991 (Oct.).
Harlow et al. "Antibodies A Laboratory Manual" Cold Spring Harbor Laboratory, 1988 p. 287.
Mendelsohn, in "Monoclonal Antibody Therapy", H. Waldmann Ed., Kanger 1988 pp. 147-160.
Sato et al. Mol. Biol. Med. 1:511-579, 1983.
Gordon et al. in "Handbook of Experimental Immunology" vol. 2.
Weir et al. Eds., Blackwell Scientific Publ., 1986, pp. 43.1-43.15.
Ashman et al. J. Cellular Physiology 158:545-554, 1994.
Hirata et al. J. Immunology 143:2900-2906, 1989.
Strohmeyer et al. Cancer Res. 51:1811-1816, 1991.
Yarden et al., Embo Journal, "Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand", vol. 6, No. 11, pp. 3341-3351, 1987.
Ashman, Journal of Cellular Biochemistry, "A murine monoclonal antibody to the human c-kit proto-oncongene product SCF receptor effect on the growth of hemopoietic urogenitor cells in-vitro and expression of c-kit in AML.," Supplement 15F, 1991.
L. Ashman et al., Leukemia Research, vol. 14, No. 7, pp. 637-644, 1990.
V. C. Broudy et al., Clinical Research, vol. 39, No. 2, 1991.

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