Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-07-01
1992-05-12
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303877, 5303879, 53038885, 435 7021, 4351722, 43524027, 435 723, 424 858, 436548, 935104, 935108, 935110, C12Q 100, G01N 3353, C07K 1528, C12N 520
Patent
active
051127377
ABSTRACT:
Monoclonal antibodies reactive with oncogenic and activated ras p21 proteins containing aspartic acid or valine at position 13 and unreactive with normal ras p21 proteins containing glycine at position 13. The antibodies are secreted by hybridomas obtained by immunizing mice with synthetic peptides corresponding in amino acid sequence to positions 5-19 or normal ras p21 proteins, except having aspartic acid or valine in place of glycine at position 13 and except for the addition of cysteine at the amino terminal end of the peptide. The antibodies and immunoreactive fragments are useful in the diagnosis, staging and classification of malignant and premalignant lesions.
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Applied Biotechnology, Inc.
Bronstein Sewall P.
Budens Robert D.
Eisenstein Ronald I.
Moskowitz Margaret
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