Monoclonal antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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Details

536 2353, 4353201, 435343, 4241331, 4241531, C07K 1900, C07H 2104, A61K 39395

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active

059199105

ABSTRACT:
The present invention provides DNA sequences encoding complementarity determining regions of variable domains of human anti-RhD antibodies and their use in the production of recombinant chimeric antibody molecules. Chimeric antibody molecules against the Rhesus (D) antigen or an antigen binding fragment thereof, as well as anti-Rhesus (D) reagents and pharmaceutical compositions comprising said chimeric antibodies are also provided.

REFERENCES:
Morrison et al., Clin. Chem., 34(9):1668 (Sep. 1988).
Riechmann et al., Nature, 332:323-327 (Mar. 1988).
Verhoeyen et al., Bio Essays, 8(2):74-78 (Feb.-Mar. 1988).

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