Chemistry: analytical and immunological testing – Involving production or treatment of antibody – Monoclonal antibody
Patent
1985-01-11
1988-06-28
Tarcza, John E.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
Monoclonal antibody
43524027, 435948, 530387, 530402, 530808, 424 85, 935104, 935107, A61K 3900, G01N 3354, C12N 500, C12R 191
Patent
active
047538945
ABSTRACT:
Murine monoclonal antibodies are prepared and characterized which bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are described.
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Bjorn Michael J.
Frankel Arthur E.
Ring David B.
Cetus Corporation
Ciotti Thomas E.
Fineman Elliott L.
Giotta Gregory J.
Tarcza John E.
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