Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-05-06
1992-12-08
Kepplinger, Esther L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
436548, 436 64, 436813, 530808, 530864, 935106, 935110, 4351722, 435 723, 43524027, C12N 512, C07K 1514, G01N 33574
Patent
active
051697742
ABSTRACT:
Murine monoclonal antibodies, or fragments thereof, that bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are described.
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Frankel Arthur E.
Laird Walter
Ring David B.
Bortner Scott R.
Cetus Oncology Corporation
Giotta Gregory J.
Kepplinger Esther L.
McGarrigle Philip L.
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