Monoclonal anti-ganglioside antibody and its preparation

Details Monoclonal anti-ganglioside antibody and its preparation Monoclonal anti-ganglioside antibody and its preparation

1994-10-20

1998-03-24

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424 149, 4241381, 4241741, 435 7011, 4351722, 435329, 435330, 435344, 4353441, 5303877, 53038885, A61K 39395, A61K 3944, C07K 1630, C12N 512

Patent

active

057309817

ABSTRACT:
The invention relates to monoclonal antibodies of high avidity, which react specifically with the gangliosides GD3 and GQ1b, and to their use for detecting melanomas and other tumors or tissues expressing GD3 and GQ1b.

REFERENCES:
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Dippold, W., et al., "Inhibition of Human Melanoma Cell Growth in Vitro by Monoclonal Anti-G.sub.D3 -Ganglioside Antibody," Cancer Res., 44:806-810 (Feb. 1984).
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Ozawa, H., et al., "Generation of one set of monoclonal antibodies specific for b-pathway ganglio-series gangliosides," Biochimica et Biophysica Acta, 1123(2):184-190 (Jan. 24, 1992).
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Ohta, S., et al., "Antitumor effects of a novel monoclonal antibody with high binding affinity to ganglioside GD3," Cancer Immunol. Immunother., 36:260-266 (1993).
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A Monosialoganglioside Is a Monoclonal Antibody-Defined Antigen of Colon Carcinoma, Magnani et al., Science, 212:55-56 (1982).
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Immune and Nonimmune Effector Functions of IgG3 Mouse Monoclonal Antibody R24 Detecting the Disialoganglioside GD3 on The Surface of Melanoma Cells, Welt et al., Clin. Immunol. Immunopathol., 45:214-229 (1987).
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