Monoclonal anti-alpha-amylase antibody which non-specifically in

Details Monoclonal anti-alpha-amylase antibody which non-specifically in Monoclonal anti-alpha-amylase antibody which non-specifically in

1986-02-07

1989-09-05

Warren, Charles F.

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 514 21, 435201, A61K 39395

Patent

active

048637289

ABSTRACT:
The present invention provides a monoclonal anti-alpha-amylase antibody which non-specifically inhibits the enzyme activity of human alpha-amylase by more than 90%.
The present invention also provides a process for obtaining this monoclonal antibody and a medicament containing it.

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patent: 4544631 (1985-10-01), Rauscher et al.
patent: 4622295 (1986-11-01), Ikenaka et al.
patent: 4623714 (1986-11-01), Veitesy et al.
patent: 4649108 (1987-03-01), Blair
Gerber et al., "Specific Immumoassay of .alpha.-Amylase Isoenzymes in Human Serum", Clin. Chem. v. 31(8), 1331-1334, 1985.
Dahlback et al., "The Non-Specific Enhancement of Allergy", Allergy, vol. 38, 261-271, 1983.
Langley et al., "Comparative Effects of Antisera to Human Pancreatic .alpha.-Amylase on Serum Amylases of Several Mammalian Species", Comp. Biochem. Physiol., vol. 55B, 563-565, 1976.
Kohler et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity,"Nature, vol. 256, pp. 495-497, 1975.
Wallenfells et al., Carb. Res. 61: 359-368, (1978).

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