Monochromatic fluid treatment systems

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

Reexamination Certificate

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C435S002000, C435S173100, C250S492100, C422S024000, C422S044000

Reexamination Certificate

active

10661262

ABSTRACT:
Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include specific wavelengths, novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and/or processing results in application modalities that employ a broad range of photo-activated and/or photo-responsive materials and/or compounds.

REFERENCES:
patent: 3637342 (1972-01-01), Veloz
patent: 3987306 (1976-10-01), Simpson
patent: 4101424 (1978-07-01), Schooley et al.
patent: 4608255 (1986-08-01), Kahn et al.
patent: 4726949 (1988-02-01), Miripol et al.
patent: 4837484 (1989-06-01), Eliasson et al.
patent: 4866282 (1989-09-01), Miripol et al.
patent: 4952812 (1990-08-01), Miripol et al.
patent: 5030200 (1991-07-01), Judy et al.
patent: 5150705 (1992-09-01), Stinson
patent: 5194740 (1993-03-01), Kogelschatz et al.
patent: 5232844 (1993-08-01), Horowitz et al.
patent: 5290221 (1994-03-01), Wolf, Jr. et al.
patent: 5433738 (1995-07-01), Stinson
patent: 5446289 (1995-08-01), Shodeen et al.
patent: 5597722 (1997-01-01), Chapman et al.
patent: 5626768 (1997-05-01), Ressler et al.
patent: 5654443 (1997-08-01), Wollowitz et al.
patent: 5702432 (1997-12-01), Chen et al.
patent: 5709991 (1998-01-01), Lin et al.
patent: 5730934 (1998-03-01), Holbert
patent: 5762867 (1998-06-01), D'Silva
patent: 5789150 (1998-08-01), Margolis-Nunno et al.
patent: 5798238 (1998-08-01), Goodrich, Jr. et al.
patent: 5834784 (1998-11-01), Morgan et al.
patent: 5843143 (1998-12-01), Whitehurst
patent: 5843374 (1998-12-01), Sizer et al.
patent: 5922278 (1999-07-01), Chapman et al.
patent: 5951509 (1999-09-01), Morris
patent: 5955840 (1999-09-01), Arnold et al.
patent: 6113566 (2000-09-01), Schlecher
patent: 6171549 (2001-01-01), Kent
patent: 6171777 (2001-01-01), Cook et al.
patent: 6190608 (2001-02-01), Laub et al.
patent: 6190609 (2001-02-01), Chapman et al.
patent: 6194821 (2001-02-01), Nakamura
patent: 2002/0015662 (2002-02-01), Hlavinka
Oppenlander, T. “Photochemical treatment of water: Comparison of incoherent excimer lamps with a medium-pressure mercury lamp” Chem. Eng. Technol. (1998) 21(6): 502-505.
Prodouz et al. “Use of laser-UV for inactivation of virus in blood products” Blood (1987) 70(2): 589-592.
Kogelschatz et al. “High-intensity sources of incoherent UV and VUV excimer radiation for low-temperature materials processing” Appl. Surface Sci. (2000) 168: 29-36.
de With et al. “UV-B-laser induced DNA damage in lymphocytes observed by single-cell gel electrophoresis” J. Photochem. Photobiol. (1994) 24: 47-53.
Coogan, J. “Pathogen control in complex fluids with water-coupld excimer lamps at 282 and 308 nm” Photochemistry and Photobiology (2005) 81: 1511-1517.
Database CAPLUS on STN, AN 1999:711834. Lomaev et al. ‘Sealed Efficient Excilamps Excited by a Capacitive Discharge’. Technical Physics Letters. 1999, vol. 25, No. 11, pp. 858-859. See entire document.
Database CAPLUS on STN, AN 2000:608262. Sosnin et al. ‘Capacitive Discharge Excilamps’. Proceedings of SPIE-The International Society for Optical Engineering. 2000, 3933 (Laser Applications in Microelectronic and Optoelectronic Manufacturing V), pp. 425-431. See entire document.
Database CAPLUS on STN, AN 1998:473216. Zhang et al. ‘Efficient XEI Excimer Ultraviolet Sources from a Dielectric Barrier Discharge’. Journal of Applied Physics. 1998, vol. 84, No. 3, pp. 1174-1178. See entire document.
Database CAPLUS on STN, AN 1997:663032. Falkenstein et al. ‘The Development of a Silent Discharge-Driven XeBr Excimer UV Light Source’. Journal of Physics D: Applied Physics. 1997, vol. 30, No. 19, pp. 2704-2710. See entire document.
PCT International Search Report, Jul. 12, 2002.
J. C. G. Doery, et al., Introduction of Aggregation of Human Blood Platelets by Ultraviolet Light: Action Spectrum and Structural Changes, Oct. 1973, vol. 42, No. 4, pp. 551-555.
D. H. Pamphilon, et al., Applications of Ultraviolet Light in the Preparation of Platelet Concentrates, 1989, vol. 29, No. 5, pp. 379-383.
G. Andreu, et al., Ultraviolet Irradiation of Platelet Concentrates: Feasibility in Transfusion Practice, vol. 30, No. 5, 1990, pp. 401-406.
Gerard Olack, et al., Improved High-Performance Liquid Chromatographic Analysis of 8-Methoxypsoralen Monoadducts and Cross-Links in Polynucleotide, DNA, and Cellular Systems: Analysis and Split-Dose Protocols, 1993, vol. 57, No. 6, pp. 941-949.
Gasparro, et al., Research Note—The Excitation of 8-Methoxypsoralen With Visible Light: Reversed Phase HPLC Quantitation of Monoadducts and Cross-Links, 1993, vol. 57, No. 6, pp. 1007-1010.
Schmitt, et al., New Trends in Photobiology (Invited Review)—Psoralen -Protein Photochemistry—a Forgotten Field, 1995, pp. 101-107.
Blundell, et al., A Prospective, Randomized Study of the Use of Platelet Concentrates Irradiated With Ultraviolet-B Light in Patients With Hematologic Malignancy, 1996, vol. 36, No. 4, pp. 296-302.
Chin, et al., Symposium-in-Print—Virucidal Treatment of Blood Protein Products with UVC Radiation, 1997, vol. 65, No. 3, pp. 432-435.
Preuss, et al., Comparison of Two Different Methods for Inactivation of Virusese in Serum, Sep. 1977, Clinical and Diagnostic Laboratory Immunology, vol. 4, No. 5, pp. 504-508.
The New England Jornal of Medicine, Leukocyte Reduction and Ultraviolet B Irradiation of Platelets to Prevent Alloimmunization and Refractoriness to Platelet Transfusions, Dec. 25, 1997, vol. 337, No. 26, pp. 1861-1869.
Corash, Inactivation of Viruses, Bacteria, Protozoa, and Leukocytes in Platelet Concentrates: Current Research Perspectives, Copyright © 1999, Transfusion Medicine Reviews, vol. 13, No. 1, pp. 18-30.
MacDonald, et al., Infrequent Detection of TT Virus Infection in Intravenous Drug Users, Prostitutes, and Homosexual Men, Mar. 1999, The Journal of Infectious Diseases, pp. 686-689.
M.L.U. del Rosario, et al., Prevention of Graft-Versus-Host Disease by Induction of Immune Tolerance With Ultraviolet B-Irradiated Leukocytes in H-2 Disparate Bone Marrow Donor, May 15, 1999, Blood, vol. 93, No. 10, pp. 3558-3564.
Goodrich, The Use of Riboflavin for the Inactivation of Pathogens in Blood Products, 2000, Vox Sanguinis, vol. 78, Supp. 2, pp. 211-215.
Prince, et al., Strategies for Evaluation of Enveloped Virus Inactivation in Red Cell Concentrates Using Hypericin, 2000, Photochemistry and Photobiology, vol. 72, No. 2, pp. 188-195.
Azuma, et al. Comparison of Sensitivity to Ultraviolet B Irradiation Between Human Lymphocytes and Hematopoietic Stem Cells, Oct. 1, 2000, Blood, vol. 96, No. 7, pp. 2632-2634.

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