Monobasic disobutamide derivatives

Details Monobasic disobutamide derivatives Monobasic disobutamide derivatives

1990-01-19

1992-03-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548540, C07D 2132

Patent

active

050970356

ABSTRACT:
Compositions of matter are disclosed of compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y represents --CN, --CONH.sub.2, --CON(R.sub.1).sub.2 or --CO.sub.2 R.sub.1 where R.sub.1 is a lower alkyl; m is the integer 1 or 2 and n is an integer from 1 to 3 inclusive; R.sub.2 represents lower alkyl; R.sub.3 represents lower alkyl or acetyl, aroyl, phenacetyl or trifluoroacetyl; A, B, and D are carbonyl or methylene such that when one of A, B, or D is carbonyl, the others are methylene and R.sub.3 is lower alkyl, whereas when R.sub.3 is acetyl, aroyl, phenacetyl or trifluoroacetyl, A, B, and D are methylene. These compounds have utility as antiarrhythmic agents.

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Yen et al., J. Med. Chem, "Compounds Related to 4-diisopropylamino-2-phenyl-2-(2-pyridyl) Gatyramide," 17, (11), pp. 1131-1135 (1974).
Yonan et al., J. Med. Chem., "Synthesis and Antiarrgthmic Activity of .alpha.,.alpha.-Bis[(dialaylamino)alkyl] phenylacetamides", 23, pp. 1102-1108 (1980).

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