Monobasic disobutamide derivatives

Details Monobasic disobutamide derivatives Monobasic disobutamide derivatives

1984-07-09

1987-01-27

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546230, 546232, 546226, 546216, 546233, 548567, 548540, C07D20704, C07D21106

Patent

active

046395245

ABSTRACT:
Compositions of matter are disclosed of compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y represents --CN, --CONH.sub.2, --CON(R.sub.1).sub.2 or --CO.sub.2 R.sub.1 where R.sub.1 is a lower alkyl; m is the integer 1 or 2 and n is an integer from 1 to 3 inclusive; R.sub.2 represents lower alkyl; R.sub.3 represents lower alkyl or acetyl, aroyl, phenacetyl or trifluoracetyl; A, B, and D are carbonyl or methylene such that when one of A, B, or D is carbonyl, the others are methylene and R.sub.3 is lower alkyl, whereas when R.sub.3 is acetyl, aroyl, phenacetyl or trifluoroacetyl, A, B, and D are methylene. These compounds have utility as antiarrhythmic agents.

REFERENCES:
patent: 2776282 (1957-01-01), Cusic
patent: 3639476 (1972-02-01), Eberle et al.
patent: 4107205 (1978-08-01), Renbarger et al.
patent: 4153797 (1979-05-01), Renbarger et al.
patent: 4217306 (1980-08-01), Yonan
Goodman & Gillman 4th Ed. (1970) MacMillan Co. N.Y. p. 397.

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