Monoamino 2,4,5-trisubstituted oxazoles

Details Monoamino 2,4,5-trisubstituted oxazoles Monoamino 2,4,5-trisubstituted oxazoles

1975-12-17

1978-02-07

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424272, 542408, 542418, C07D26334

Patent

active

040726894

ABSTRACT:
Pharmacologically active 2,4,5-trisubstituted oxazoles of the general formula ##STR1## wherein A is cyclohexyl, thienyl or a group of the formula ##STR2## in which R represents one to three substituents each independently selected from the group consisting of hydrogen, lower alkyl, halo, halo-lower alkyl, lower alkoxy, nitro, cyano, amino, carbamoyl, acetamino or carboxy; one of the R.sub.1 and R.sub.2 groups is a lower alkyl group and the other is an amido group, ##STR3## wherein R.sub.3 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl, hydroxy, amino, lower alkylideneamino, cycloalkylideneamino, benzylideneamino and R.sub.4 is selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl, or R.sub.3 and R.sub.4 taken together with the nitrogen atom may also form a 5- to 7-membered hetero ring which may contain one other hetero atom selected from N, O and S. The compounds have antiinflammatory activity.

REFERENCES:
"Beilsteins Handbuch der Org. Chemie.," Band XXVII, Syst. #4309, p. 324, (1937).
Zerilli et al., "Chem. Abst.," vol. 78, (1973), Abst. No. 92286j.
Sycheva et al., "Chem. Abst.," vol. 58, (1962), p. 1443h.
Finar, "Organic Chem.," vol. 1, p. 189, (1959), 3rd Ed.

Affiliated with

Also associated with

Rating

Monoamino 2,4,5-trisubstituted oxazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoamino 2,4,5-trisubstituted oxazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoamino 2,4,5-trisubstituted oxazoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1400615