Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2005-04-22
2010-02-16
Kwon, Brian-Yong S (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S546000, C514S560000
Reexamination Certificate
active
07662853
ABSTRACT:
The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significantly effect for immuno modulation including immune enhancing. In the case of inducing cancer in a hamster by injecting cancer cell line, cancer development was delayed by activating lymphocytes, monocytes, and dendritic cells that are important factors to promote immunity and apoptosis of cancer cell was induced by promoting cytotoxicity of immune cell against cancer cell. Also in the case of mouse induced septic shock, it shows 100% survival rate even after lapse of 120 hours by control of immune function and suppression effect apoptosis. Therefore, mono acetyl diacyl glycerol derivatives according to the present invention can be effectively used for an immunomodulating agent, a sepsis treatment, a cancer treatment, and a health food for an immune modulation or the prevention of cancer.
REFERENCES:
patent: 2003/0032674 (2003-02-01), Hwang
patent: 10-2005-0103259 (2005-10-01), None
patent: WO 99/26640 (1999-06-01), None
patent: WO 03/063793 (2003-08-01), None
Lambert, Eur J Pharam Sci, 11 (suppl 2): S15-S27, 2000.
PDF Merck Manual regarding “Sepsis”.
Suh, Jeong S., et al., Triacylglycerol, 1-Palmitoy1-2-Linoleoyl-3-Acetyl-rac-Glycerol Isolated from Bovine Udder . . . , Cellular Physiology and Biochem., 13: 415-422 (2003).
Suh, Jeong-Sook, et al., Phagocytic Activity of Ethyl Alcohol Fraction of Deer Antler in Murine Peritoneal Macrophage, Biol. Pharm., Bull., 22: 932-935 (1999).
Kim, MiJung, et al., The Effects of GM-CSF, SCF and Deer Antler Extracts on the Mouse Hematopoietic Cells, Korea J. BRM, 4(1): 47-53 (1994).
Kim, Sang Hee, et al., Biological Effects of Deer Antler Extracts on Hematopoietic System, Korean J. BRM, 3(1): 23-30 (1993).
Ouyang, Yanli, et al., Suppression of Interleukin-2 by the Putative Endogenous Cannabinoid 2-Arachidonyl-Glycerol . . . , Molecular Pharm., 53: 676-683 (1998).
Baek Bong-Sook
Elmore Carolyn S.
Elmore Patent Law Group P.C.
Issac Roy P.
Kwon Brian-Yong S
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