Mono-specific polyclonal antibodies and methods for...

Details Mono-specific polyclonal antibodies and methods for... Mono-specific polyclonal antibodies and methods for...

2007-02-20

2007-02-20

Navarro, Mark (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S350000, C435S007200, C436S533000

Reexamination Certificate

active

10224752

ABSTRACT:
A method is provided for the purification ofClostridium difficileToxin A antigen comprising reacting impure Toxin A with immobilized mono-specific polyclonal antibodies. The polyclonal antibodies are coupled to a hydrazide group containing matrix such as hydrazide activated agarose gel. The immobilized antibody is specific for Toxin A and will greatly purify Toxin A from a Toxin A containing solution. Antibodies raised to Toxin A purified according to the method are of higher activity than antibodies produced from prior art purified Toxin A.

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