Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-03-20
1996-12-31
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540455, 540468, 540452, 544138, 544316, 546277, 5462691, 548131, 548110, C07D29108, A61K 31395
Patent
active
055894739
ABSTRACT:
The present invention relates to a compound of the formula ##STR1## wherein X.sup.1, R.sup.1, R.sup.2, OP, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.0 are as described herein, and their pharmaceutically acceptable salts thereof carrying an acidic and/or basic substituent.
The compound of formula I as well as their pharmaceutically acceptable salts inhibit DNA gyrase activity in bacteria and possess antibiotic, especially antibacterial activity against microorganisms and can be used in the control or prevention of infectious diseases.
REFERENCES:
patent: 5294609 (1994-03-01), Arisawa et al.
Kamiyama et al., Chemical Abstract 120:212154z (1994).
Goetschi et al, Chem. Abstract 121:124616 (1993).
The Merck Manual, 15th edition (1987), Berkow, M.D. editor, p. 46.
Goetschi, E., et al., Pharmac. Ther., 60:367-380 (1993).
Kamiyama, Tsutomu, et al., The Journal of Antibiotics, 47(1): 37-45 (1993).
G otschi Erwin
Geiwiz J urgen
Hebeisen Paul
L ubbers Thomas
Link Helmut
Datlow Philip I.
Hoffmann-La Roche Inc.
Johnston George W.
Kass Alan P.
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