Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-10-11
1997-09-09
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548131, 544138, 544310, 5462724, 5462727, 5462681, 5462691, A61K 3141, C07D29108
Patent
active
056657463
ABSTRACT:
The present invention relates to a compound of the formula ##STR1## wherein X.sup.1, R.sup.1, R.sup.2, OP, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.0 are as described herein, and their pharmaceutically acceptable salts thereof carrying an acidic andr basic substituent.
The compound of formula I as well as their pharmaceutically acceptable salts inhibit DNA gyrase activity in bacteria and possess antibiotic, especially antibacterial activity against microorganisms and can be used in the control or prevention of infectious diseases.
REFERENCES:
patent: 5294609 (1994-03-01), Arisawa et al.
Goetschi, E., et al., Pharmac. Ther., 60:367-380 (1993).
Goetschi, E., et al., Chemical Abstract 121:124616 (1993).
Kamiyama, Tsutomu, et al., The Journal of Antibiotics, 47(1):37-45 (1993).
Kamiyama, Tsutomu, et al., Chemical Abstract 120:212154z (1994).
The Merck Manual, 15th ed. (1987), Berkow, M.D., editor, p. 46.
Geiwiz Jurgen
Gotschi Erwin
Hebeisen Paul
Link Helmut
Lubbers Thomas
Gerstl Robert
Hoffmann-La Roche Inc.
Johnston George W.
Kass Alan P.
Tramaloni Dennis P.
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