Monitoring amplification with fret probes

Details Monitoring amplification with fret probes Monitoring amplification with fret probes

2007-01-09

2007-01-09

Horlick, Kenneth R. (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S091200

Reexamination Certificate

active

10397759

ABSTRACT:
The present invention is directed to kits for monitoring a nucleic acid during amplification. More particularly, the present invention relates to kits comprising a first oligonucleotide labeled with a first fluorophore, a second oligonucleotide labeled with a second fluorophore, and components for amplifying the locus, wherein the first and second fluorophores comprise a fluorescence resonance energy transfer pair. Hybridization of at least the first oligonucleotide to the amplified locus places the first and second fluorophores in a resonance energy transfer relationship.

REFERENCES:
patent: 5593840 (1997-01-01), Bhatnagar et al.
patent: 5814492 (1998-09-01), Carrino et al.
patent: 6140054 (2000-10-01), Wittwer et al.
patent: 6482590 (2002-11-01), Ullman et al.
patent: 6911310 (2005-06-01), Heller
patent: WO 93/20240 (1993-10-01), None

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