Monensin urethane derivatives produced by streptomyces

Details Monensin urethane derivatives produced by streptomyces Monensin urethane derivatives produced by streptomyces

1980-11-10

1981-10-13

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435118, 435886, C12P 1926, C12P 1716

Patent

active

042949254

ABSTRACT:
Monensin urethane derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, wherein R.sub.4 is alkyl, aryl, alkylaryl, arylalkyl, haloaryl, nitroaryl, haloarylalkyl, alkoxyaryl, aryloxyaryl, arylcycloalkyl, acylaryl and cycloalkyl; R.sub.2 is methyl or ethyl and R.sub.3 is-CONHR.sub.4
and their pharmaceutically acceptable salts.
The compounds exhibit antimicrobial activity and activity as growth promotant agents in ruminants. Further activities for this series of compounds are anticoccidial activity, antihypertensive activity, antimalarial activity and as agents in the treatment of swine dysentery.
Also disclosed are a fermentative process and a semisynthetic process for producing the urethane derivatives.

REFERENCES:
patent: 3501568 (1970-03-01), Haney et al.
patent: 3832358 (1974-08-01), Chamberlin
patent: 4138481 (1979-02-01), Martin et al.

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