Molecules with antibody combining sites that exhibit catalytic p

Details Molecules with antibody combining sites that exhibit catalytic p Molecules with antibody combining sites that exhibit catalytic p

1988-08-19

1992-06-30

Patterson, Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Catalytic antibody

435212, 435219, 435228, 5303889, C12N 980, C12N 948, C12N 950

Patent

active

051262584

ABSTRACT:
An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to the analog-ligand and also to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site.

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