Molecules with antibody combining sites that catalyze carbocycli

Details Molecules with antibody combining sites that catalyze carbocycli Molecules with antibody combining sites that catalyze carbocycli

1994-01-10

1995-01-24

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing hydrocarbon

4351885, 43524027, C12P 500, C12N 900, C12N 512

Patent

active

053842529

ABSTRACT:
The present invention contemplates monoclonal antibody combining site-containing molecules that catalyze the formation of a 6-membered ring compound from a 5,6-ethylenically-unsaturated-1-sulfonate substrate. The catalytic molecules bind to the substrate molecule as well as to a structural analog of the substrate that is a piperidine N-oxide whose nitrogen atom is in the same relative position in that ring as the sulfonate-bearing carbon atom of the open-chain substrate. A hybridoma that secretes the catalytic molecules and a process for forming a 6-membered ring compound that utilizes the catalytic molecules are also disclosed.

REFERENCES:
patent: 4900674 (1990-02-01), Benkovic et al.
Janda, K. D., et al. (1993) Science 259, 490-493.
Ashley, J. A., et al. (1992) J. Org. Chem 57, 6691-6693.
Li et al., Science, 264:1289-1293 (May 27, 1994).
Borman, C&EN, 3:43-44 (Jun. 13, 1994).

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