Molecules of the PYRIN/NBS/LRR protein family and uses thereof

Details Molecules of the PYRIN/NBS/LRR protein family and uses thereof Molecules of the PYRIN/NBS/LRR protein family and uses thereof

2007-01-09

2007-01-09

Canella, Karen A. (Department: 1643)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S252300, C435S254110, C435S325000, C536S023500

Reexamination Certificate

active

10066521

ABSTRACT:
Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 1 285 964 (2003-02-01), None
patent: WO 01/61005 (2001-08-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 01/92527 (2001-12-01), None
patent: WO 02/14500 (2002-02-01), None
patent: WO 02/32955 (2002-04-01), None
patent: WO 02/40668 (2002-05-01), None
patent: WO 02/48362 (2002-06-01), None
U.S. Appl. No. 60/249,401.
Houdebine, Journal of Biotechnology, 1994, vol. 34, pp. 269-287.
Orkin, “Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy”.
Eck et al (Gene-Based Therapy, In: The Pharmacological Basis of Therapeutics, Goodman and Gilman, Ed.s, 1996, pp. 77-101).
Verma et al (Nature, 1997, vol. 389, pp. 239-242).
Mathews and Van Holde, Biochemistry, 1996, pp. 165-171.
Matthews, B. “Genetic and Structural Analysis of the Protein Stability Problem”, In: Perspectives in Biochemistry, Neurtah Ed., 1989).
Abstract of Ziv, et al, Advances in Research on Neurodegeneration, 1997, vol. 3-4, pp. 195-202.
Tong et al., (2002) “A human homologue of mouseMater, a maternal effect gene essential for early embryonic development”, Human Reproduction 17(4):903-911.
Bertin et al., “the pyrin domain: A novel motif found in apoptosis and inflammation proteins”, Cell Death Differentiation, Edward Arnold, Oxford, Great Britain, 12(7):1273-1274 (2000).
Dias Neta et al., “IL2-UT0074-040900-153-G02 UT0074 homo sapiens cDNA, mRNA sequence”, Database accession No. BF380801.
DOE Joint Genome Institute, GenBank Accession No. AC012310 (2001).
Martinon et al., GenBank Accession No. AF442488 (2001).
Masumoto et al., “Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligmerization of ASC”, Biochemical and Biophysical Research Communications, Academic Press Inc., Orlando, FL, USA, 280(3):652-655 (2001).
Strausberg, GenBank Accession No. BE278926 (2000).
Zhao et al., “CITBI-E1-2565K18.TF CITBI-E1 homo sapiens genomic clone 2565K18, genomic survey sequence”, Database Accession No. AQ424752 XP002269231.

Affiliated with

Also associated with

Rating

Molecules of the PYRIN/NBS/LRR protein family and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Molecules of the PYRIN/NBS/LRR protein family and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecules of the PYRIN/NBS/LRR protein family and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3785516