Molecules of the HKID-1-related protein family and uses thereof

Details Molecules of the HKID-1-related protein family and uses thereof Molecules of the HKID-1-related protein family and uses thereof

1999-01-26

2000-11-07

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 435 911, 4352523, 4353201, 435325, 536 232, C12N 912, C12N 1554

Patent

active

061435406

ABSTRACT:
Novel HKID-1 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length HKID-1 proteins, the invention further provides isolated HKID-1 fusion proteins, antigenic peptides and anti-HKID-1 antibodies. The invention also provides HKID-1 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an HKID-1 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
Feldman et al. KID-1, a Protein Kinase Induced by Depolarization in Brain, J. Biol. Chem. 273(26): 16535-16543, Jun. 23, 1998.
Meeker et al., Cloning and Characterization of the Human PIM-1 Gene: A Putative Oncogene Related to the Protein Kinases, J. Cell. Biochem. 35: 105-112, 1987.
Zakut-Houri et al. The cDNA sequence and gene analysis of the human pim oncogene, Gene 54: 105-111, 1987.

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