Molecules of the card-related protein family and uses thereof

Details Molecules of the card-related protein family and uses thereof Molecules of the card-related protein family and uses thereof

2002-12-20

2008-11-18

Helms, Larry R. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C536S023100

Reexamination Certificate

active

07452967

ABSTRACT:
Novel CARD-9,CARD-10,or CARD-11polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9,CARD-10,or CARD-11proteins, the invention further provides CARD-9,CARD-10,or CARD-11,fusion proteins, antigenic peptides and anti-CARD-9,CARD-10,or CARD-11antibodies. The invention also provides CARD-9,CARD-10,or CARD-11nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9,CARD-10,or CARD-11gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

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