Molecules of the card-related protein family and uses thereof

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S252300, C435S254110, C435S325000, C536S023500

Reexamination Certificate

active

07083944

ABSTRACT:
Novel CARD-12 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-12 proteins, the invention further provides CARD-12, fusion proteins, antigenic peptides and anti-CARD-12 antibodies. The invention also provides CARD-12 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-12 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
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Hazan et al. Genbank Accession AL121653, Sep. 30, 1999. Bethesda, MD.: National Library of Medicine (www.ncbi.nlm.nih.gov).
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Koseki et al., “CIPER, a Novel NF κB-activating Protein Containing a Caspase Recruitment Domain with Homology toHerpesvirus-2 Protein E10,” J. Biol Chemistry, 274(15):9955-9961 (Apr. 9, 1999).
GenBank Accession No. AQ309494, Adams et al. (Dec. 22, 1998).
Bertin et al., “Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB,” The Journal of Biological Chemistry, 274(19):12955-12958 (May 7, 1999).
Hofmann et al., “The CARD domain: a new apoptotic signalling motif,” TIBS 22:155-156 (1997).
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GenBank™ Accession No. AC010968, Aug. 18, 2000.
GenBank™ Accession No. AI263294, Feb. 3, 1999.
GenBank™ Accession No. AL121653, Mar. 2, 2000.
GenBank™ Accession No. Q13075, Aug. 20, 2001.
Incyte LGtemplates Accession No. 328193, LifeSeq Gold 5.0, Oct. 1999 (local alignments obtained from a BLAST search with a query sequence).
Incyte LGtemplates Accession No. 402895, LifeSeq Gold 5.0, Oct. 1999 (local alignments obtained from a BLAST search with a query sequence).

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