Molecules influencing the shedding of the TNF receptor, their pr

Details Molecules influencing the shedding of the TNF receptor, their pr Molecules influencing the shedding of the TNF receptor, their pr

1994-10-12

1997-09-09

Prouty, Rebecca E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530350, 530327, 435 692, 435226, C07K 706, C07K 14715, C07K 1481, C12N 964

Patent

active

056658591

ABSTRACT:
Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.

REFERENCES:
Francoise Porteu et al. "Human Neutrophil Elastase Releases a ligand-binding Fragment from the 75-kDa Tumor Necrosis Factor (TNF) Receptor", The Journal of Biological Chemistry, vol. 266, No. 28, pp. 18846-18853 Oct. 5, 1991.
Angelo L.S. et al. "Elastatinal, A-PMSF, and pepstatin inhibit p80 tumor necrosis factor receptor (TNF-R) shedding in activated human lymphocytes", Proceedings of the American Association for Cancer Research, vol. 34, p. 441 Mar. 1993.
Mario R.W. Ehlers et al. "Membrane Proteins with Soluble Counterparts: Role of Proteolysis in the Release of Transmembrane Proteins", Biochemistry, vol. 30, No. 42, pp. 10065-10074, Oct. 22, 1991.
Urban Gullberg et al. "Involvement of an Asn/Val cleavage site in the production of a soluble form of a human tumor necrosis factor (TNF) receptor. Site-directed mutagenesis of a putative cleavage site in the p55 TNF receptor chain", European Journal of Cell Biology, vol. 58 pp. 307-312 (1992).
J. Heimbach et al. "Affinity purification of the HIV-1 protease", Chemical Abstracts, vol. 112, No. 7, Abst. No. 51017, Feb. 12, 1990.
Chenduen Hwang et al. "A 20 amino acid synthetic peptide of a region from the 55 kDa human TNF receptor inhibits cytolytic and binding activities of recombinant human tumour necrosis factor in vitro", Proc. R. Soc. Lond. B, vol. 245, pp. 115-119 (1991).
Patrick W. Gray et al. "Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein", Proceedings of the National Academy of Sciences of USA., vol. 87 No. 19, pp. 7380-7384, Oct. 1990.

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