Molecules for iontophoretic delivery

Details Molecules for iontophoretic delivery Molecules for iontophoretic delivery

1997-02-10

1998-12-01

Bockelman, Mark

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

A61N 130

Patent

active

058430156

ABSTRACT:
The present invention relates to a method for preparing proteins or peptides for iontophoretic delivery by modifying said proteins or peptides, by hydrophobic bonding of acharged molecule to a hydrophobic region of the protein or peptide, to have an isoelectric point of less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3. Another embodiment of the present invention relates to a device for delivery of a protein or peptide having an isoelectric point of less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3.

REFERENCES:
patent: 4731049 (1988-03-01), Parsi
patent: 5203768 (1993-04-01), Haak et al.
patent: 5376107 (1994-12-01), Inagi et al.
patent: 5494679 (1996-02-01), Sage, Jr. et al.

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