Molecules containing at least one peptide sequence carrying one

Details Molecules containing at least one peptide sequence carrying one Molecules containing at least one peptide sequence carrying one

1994-05-13

1997-11-25

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

4241851, 4242681, 435 693, 530300, 530350, 530395, A61K 39015, C07K 14445

Patent

active

056909411

ABSTRACT:
The invention relates to a polypeptide characterized in that it contains at least one peptide sequence carrying one or several epitopes characteristic of a protein produced at the sporozoite stage and in the hepatocytes infected by P. falciparum, this sequence comprising a sequence of from 10 amino acids to the maximal number of amino acids of the following peptide chain sequence:

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Weber et al., "Primary structure of a Plasmodium falciparum malaria antigen located at the merozoite surface and within the parasitophorous vacuole", J. Biol. Chem. 263: 11421-11425 (1988).
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Triglia et al., "The complete sequence of the gene for the knob-associated histidine-rich protein from Plasmodium falciparum", EMBO Jour. 6: 1413-1419 (1987).
Lal et al., "Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii", J. Biol. Chem. 262: 2937-2940 (1987).
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