Molecules and methods using same for measuring...

Details Molecules and methods using same for measuring... Molecules and methods using same for measuring...

2006-08-15

2006-08-15

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C436S074000

Reexamination Certificate

active

07090995

ABSTRACT:
A molecule suitable for use as an indicator of free iron levels in a biological sample, the molecule including an iron binding moeity and a signal generating moeity, wherein an intensity of the signal generated by the signal generating moeity is related to an amount of the iron bound by the iron binding moeity.

REFERENCES:
Saito “Method of determination of iron in the form of ferrioxamine in urine” Rinsho Kagaku 1(1): 100-2 (1971).
Singh et al., “A direct method for quantification of non-transferrin-bound iron”, Analytical Biochemistry 186(2): 320-3 (1990).
Zhang et al., “An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum”, Biochemistry an Molecular Biology International 35 (3) 635-41(1995).
Loreal et al., “Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method”, Journal of Hepatology 32(5) : 727-733 (2000).
Breuer et al., “The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation”, Blood 95(9) 2975-82 (2000).
Breuer et al., “Desferrioxamine-chelatable iron, a component of serum non transferrin-bound iron, used for assessing chelation therapy”, Blood 97(3) : 792-98 (2001).
Breuer et al., “A fluorescence-based one-step assay for serum non-transferrin-bound iron”, Analytical Biochemistry 299(2) :194-202 (2001).

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