Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2006-05-09
2006-05-09
Nolan, Patrick J. (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C435S326000, C530S387100
Reexamination Certificate
active
07041290
ABSTRACT:
Disclosed are antibodies that inhibit proteolytic release of a soluble KIM-1 polypeptide from KIM-1 expressing cells. Also disclosed are methods of using the antibodies to inhibit shedding of the KIM-1 polypeptide.
REFERENCES:
patent: 5622861 (1997-04-01), Kaplan et al.
patent: 6664385 (2003-12-01), Sanicola-Nadel et al.
patent: 2003/0124114 (2003-07-01), McIntire et al.
patent: 2003/0215831 (2003-11-01), Sanicola-Nadel et al.
patent: 2004/0005322 (2004-01-01), Kuchroo et al.
patent: 2004/0180038 (2004-09-01), Hancock et al.
patent: 2005/0095593 (2005-05-01), McIntire et al.
patent: WO 96/04376 (1996-02-01), None
patent: WO 97/44460 (1997-11-01), None
patent: WO 01/98481 (2001-12-01), None
patent: WO 03/025138 (2003-03-01), None
patent: WO 03/042661 (2003-05-01), None
patent: WO 03/080856 (2003-10-01), None
patent: WO 04/005544 (2004-01-01), None
patent: WO 04/084823 (2004-10-01), None
patent: WO 05/001092 (2005-01-01), None
Rudikoff et al. 1982, Single amino acid substitution altering antigen-binding specificity, Proc. Nat. Acad. Sci., USA, 79:1979-1983.
Thompson et al. Journal of Virology, vol. 72, No. 5,p. 3751-3761, 1998.
Feigelstock et al., “The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor,” J. Virol. vol. 72, Aug. 1998, pp. 6621-6628.
Ichimura et al., “Kidney injury molecule-1 (KIM1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury,” J. Biol. Chem. vol. 273, No. 7, Feb. 1998, pp. 4135-4142.
Owens et al., “The genetic engineering of monoclonal antibodies,” J. Immunol. Methods. vol. 168, Feb. 10, 1994, pp. 149-165.
Bailly, V., et al., “Shedding of Kidney Injury Molecule-1, a Putative Adhesion Protein Involved in Renal Regeneration,” Journal of Biological Chemistry, vol. 277, No. 42, Oct. 18, 2002, pp. 39739-39748.
Kaplan et al. (1996) “Identification of a Surface Glycoprotein on African Green Monkey Kidney Cells as a Receptor for Hepatitis A Virus,” EMBO 15:4282-96.
Kuchroo, et al. (2003) “TheTimGene Family: Emerging Roles in Immunity and Disease,” Nat. Rev. Immunol. 3:454-62.
McIntire et al. (2001) “Identification ofTapr(An Airway Hyperreactivity Regulator Locus) and the LinkedTimGene Family,” Nat. Immunol. 2:1109-16.
Monney et al., (2002) “Th1-Specific Cell Surface Protein Tim-3 Regulates Macrophage Activation and Severity of an Autoimmune Disease,” Nature 415:536-41.
Bailly Veronique
Bonventre Joseph
Biogen Idec MA Inc.
Fish & Richardson P.C.
Kim Yunsoo
Nolan Patrick J.
The General Hospital Corporation
LandOfFree
Molecules and methods for inhibiting shedding of KIM-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Molecules and methods for inhibiting shedding of KIM-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecules and methods for inhibiting shedding of KIM-1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3648205