Molecules

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2007-10-30

2007-10-30

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C530S350000

Reexamination Certificate

active

10040647

ABSTRACT:
The present invention related generally to novel molecules and more particularly novel proteinaceous molecules involved in or associated with regulation of cell activities and/or viability. The present invention is particularly directed to novel serine proteinases and a novel kinase and to derivatives, agonists and antagonists thereof. In one embodiment, the present invention provides a novel serine proteinase, referred to herein as “HELA2” or “testisin”, which has roles in spermatogenesis, in suppressing testicular cancer and as a marker for cancers.

REFERENCES:
Yu et al., J.B.C., 270(22), 13483-13489, 1995.
E. Vey et al. (1996) AExpression and Creavage of Tumor . . . Factor-α and Tumor Necrosis Factor Receptors by Human Monocytic Cell Lines Upon Direct Contact With Stimulated T Cells@Eur. J. Imm. 26: 2404-2409.
Y. Nakabo and M.J. Pabst (1996) ALysis of Leukemic Cells By Human Macrophages: Inhibition by 4-(2-aminoethyl)-benzenesulfonyl Flouride (AEBSF), a Serine Protease Inhibitor@Journal of Leukocyte Biology 60: 328-336.
D.J. McConkey (1996) ACalcium-dependent, Interleukin 1β-converting Enzyme Inhibitor-insensitive Degradation of Lamin B1and DNA Fragmentation in Isolated Thymocyte Nuclei@J. Biol. Chem. 271: 22398-22406.
S.S. Choi et al. (1996) AProstaglandin-E2Regulation of Tumor Necrosis Factor Receptor Release in Human Monocytic THP-1 Cells@Cellular Immunology 170: 178-184.
J.L. Dickinson et al. (1995) APlasminogen Activator Inhibitor Type 2 Inhibits Tumor Necrosis Factor α-induced Apoptosis@The Journal of Biological Chemistry 270(46): 27894-27904.
R. Sood et al. (1997) AConstruction of a 1-Mb Restriction-mapped Cosmid Contig Containing the Candidate Region for the Familial Mediterranean Fever Locus (MEFV) on Chromosome 16p13.3″Genomics 42: 83-95.
N.A. Doggett et al. (1995) AAn Integrated Physical Map of Human Chromosome 16″Nature 377(28): 335-365; and.
L.E. Sower et al. (1996) AShort Communication: Extracellular Activities of Human Granzymes I. Granzyme A Induces IL6 and IL8 Production in Fibroblast and Epithelial Cell Lines@Cellular Immunology 171: 159-163.
E. Vey et al. (1996) AExpression and Creavage of Tumor . . . Factor-a and Tumor Necrosis Factor Receptors by Human Monocytic Cell Lines Upon Direct Contact With Stimulated T Cells@ Eur. J. Imm. 26: 2404-2409.
Y. Nakabo and M.J. Pabst (1996) ALysis of Leukemic Cells By Human Macrophages: Inhibition by 4-(2-aminoethyl)-benzenesulfonyl Flouride (AEBSF), a Serine Protease Inhibitor@ Journal of Leukocyte Biology 60: 328-3 328-336.
D.J. McConkey (1996) ACalcium-dependent, Interleukin 1β-converting Enzyme Inhibitor-insensitive Degradation of Lamin B1 and DNA Fragmentation in Isolated Thymocyte Nuclei@ J. Biol. Chem. 271: 22398-22406.
S.S. Choi et al. (1996) AProstaglandin-E2 Regulation of Tumor Necrosis Factor Receptor Release in Human Monocytic THP-1 Cells@ Cellular Immunology 170: 178-184.
J.L. Dickinson et al. (1995) APlasminogen Activator Inhibitor Type 2 Inhibits Tumor Necrosis Factor a-induced Apoptosis@ The Journal of Biological Chemistry 270 (46): 27894-27904.
R. Sood et al. (1997) AConstruction of a 1-Mb Restriction-mapped Cosmid Contig Containing the Candidate Region for the Familial Mediterranean Fever Locus (MEFV) on Chromosome 16p13.3″ Genomics 42: 83-95.
N.A. Doggett et al. (1995) AAn Integrated Physical Map of Human Chromosome 16″ Nature 377 (28): 335-365.
L.E. Sower et al. (1996) AShort Communication: Extracellular Activities of Human Granzymes I. Granzyme A Induces IL6 and IL8 Production in Fibroblast and Epithelial Cell Lines@ Cellular Immunology 171: 159-163.

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