Molecularly imprinted polymer

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

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Reexamination Certificate

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08086415

ABSTRACT:
A computer aided rational molecular design method that includes establishing a virtual library of functional monomers each having a portion that is capable of polymerizing and a functional group that is capable of interacting with a template molecule with the aid of a computer, designing a molecular model of a biological template molecule by a computer facilitated molecular mechanical method and screening said virtual library of functional monomers and selecting those monomers which have the highest binding score to the template molecule by their functional group.

REFERENCES:
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patent: 93 09075 (1993-05-01), None
Rogan et al., “Synergistic Use of Virtual Screening and Biophysical Methods for the Protein-Based Design of Peptidomimetics,” Chimia (2000) vol. 54, pp. 658-662.
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Takeuchi et al., “Molecular Imprinting: An Approach to “Tailor-Made” Synthetic Polymers with Biomimetic Functions,” Acta Polymer (1996) vol. 47, pp. 471-480.
Kempe et al. Journal of Molecular Recognition. 1993. vol. 6, on.1, pp. 25-29, abstract only.
Mosbach et al. Bio/Technology. (1996) vol. 14, pp. 163-170, abstract only.
Jin Cho Sung et al.: “Rational combinatiorial library desing. 2. Rational design of targeted combinatorial peptide libraries using chemical similarity probe and inverse QSAR approaches” J. Chem. Inf. Comput. Sci., vol. 38, No. 2 pp. 251-268 Apr. 3, 1998.
Zheng Weifan et al.: “Rational combinatiorial library desing. 1. Focus-2D: A new approach to the design of targeted combinatorial chemical libraries” J. Chem. Inf. Comput. Sci., vol. 38, No. 2 pp. 251-258 Apr. 3, 1998.
Takeuchi Toshifumi et al.: “Combinatorial molecular imprinting: an approache to synthetic polymer receptors” Anal. Chem., vol. 71, No. 2, pp. 285-290 Nov. 12, 1998.

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