Molecular transporters based on sugar and its analogues and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C514S025000, C424S009350

Reexamination Certificate

active

08058413

ABSTRACT:
The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.

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Le, G.T., Abbenante, G., Becker, B., Grathwohl, M., Halliday, J., Tometzki, G., Zuegg, J., Meutermans, W. (2003) Molecular diversity through sugar scaffolds. Drug Discovery Today, vol. 8, No. 15, p. 701-709.
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Brugidou, J., et al., “The Retro-inverso Form of a Homeobox-Derived Short Peptide is Rapidly Internalized by Cultured Neurons: A New Basis for an Efficient Intracellular Delivery System,” Biochem. Biophys. Res. Comm., vol. 214: 685-693 (1995).
Wender, P.A., Mitchell, D.J., Pattabiraman, K., Pekley, E.T., Steinman, L., Rothbard, J.B. (2000) The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters. Proceedings of the National Academy of Sciences, vol. 97, No. 24, p. 13003-13008.

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