Metal treatment – Process of modifying or maintaining internal physical... – Processes of coating utilizing a reactive composition which...
Patent
1995-08-14
1997-12-02
Drodge, Joseph W.
Metal treatment
Process of modifying or maintaining internal physical...
Processes of coating utilizing a reactive composition which...
210 93, 210 94, 356301, 422 7, 427162, 252395, C23C 2200, G01J 344, C23F 1100
Patent
active
056931522
ABSTRACT:
The present invention provides a generalized molecule-specific means of detection that can be applied to all existing separation systems with particular emphasis directed toward those methods based upon chromatographic, electrophoretic, and extractive techniques. The SERS method of detection of the present invention consists of the modification of SERS substrates by the application of a stabilizing coating that also reproduces or mimics the specific separation process being utilized. This ability to reproduce the specific separation process at the detector makes this method of detection universal for all types of analytes and separation methods. The detector of the present invention contains a noble metal foil, usually silver, that has been roughened to produce the SERS effect or a SERS active noble metal film that has been deposited onto a transparent substrate. A particularly unique feature of the invention is the use of stabilizing coatings with the SERS substrates. The coating is attached to the SERS substrate through chemical bonds such as thiol linkages or through physisorb polymeric coatings.
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Drodge Joseph W.
Hein William E.
University of Wyoming
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