Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-01-29
2008-01-29
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
10333895
ABSTRACT:
The present invention relates generally to genetic sequences exhibiting differential expression patterns in cancer tissue relative to normal tissue. The identification of differentially expressed genetic sequences permits their use as molecular markers for cancer, as early indicators of cancer progression and/or as predictive markers for a propensity or likelihood of a cancer to develop. The present invention relates particularly to genetic sequences exhibiting expression patterns up-regulated in cervical cells or associated with pre-, early- or late-onset cervical cancer relative to normal cervical cells. The genetic sequences of the present invention provide markers for early- or late-onset cervical cancer and/or a cancer related to cervical cancer. The markers of the present invention further provide potential targets for the development of therapeutic protocols for the treatment or prophylaxis of cervical or related cancer. Such therapeutic protocols are directed to inhibiting expression of the marker or inhibiting the expression product of the marker. The present invention is further directed to a method for identifying molecular markers which are useful indicators of cervical cancer and/or its progression.
REFERENCES:
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Sales et al (The Journal of Clinical Endocrinology and Metabolism, May 2001, 86(5): 2243-2249).
Muller et al (JNCI, Mar. 18, 1998, 90(6):433-439).
Shim, C., et al., “Profiling of Differentially Expressed Genes in Human Primary Cervical Cancer . . . ,” Clinical Cancer Research, 4:3045-3050, (1998).
Nees, M., et al., “Identification of novel molecular markers which correlate with HPV-induced tumor progression,” Oncogene, 16:2447-2458, (1998).
Huang, G.M., et al., “Prostate Cancer Expression Profiling by cDNA Sequencing Analysis,” Genomics, 59:178-186, (1999).
Cheng, Q., et al., “Identification and Characterization of Genes Involved in the Carcinogenesis of Human . . . ,” Int. J. Cancer, 98:419-426, (2002).
EMBL Accession No. XP-002363719 “Homo sapienscDNA clone,” NCI-CGAP, Jun. 24, 1997.
Embl Accession No. XP-002363720, “Homo sapiensgenomic clone RPCI-11-274E21, genomic survey sequence,” Zhao, S., et al., Apr. 29, 1999.
Bae, M-K, “Identification of Genes Differentially Expressed by Hypoxia in Hepatocellular Carcinoma Cells,” Biochem. Biophys. Res. Comm. 243:158-162, (1998).
Hashimoto, Y., et al., “Identification of Genes Differentially Expressed in Association with Metastatic Potential of K-1735 . . . ,” Cancer Res., 56:5266-5271, (1996).
Fung, L.F., et al., “Identification of genes differentially expressed in nasopharyngeal carcinoma by messenger . . . ,” International Journal of Oncology, 13:85-89, (1998).
EMBL Accession No. AL117339, “Human DNA sequence from clone RP11-508N22 on chromosome 10 . . . ,” Wilson, S., Sep. 10, 1999.
EMBL Accession No. AL035705, “Human DNA sequence from clone RP4-758N20 on chromosome 1p31.3-32.2 . . . ,” Cobley, V., Mar. 12, 1999.
Hattori, M., et al., “The DNA sequence of human chromosome 21,” Nature, 405:311-319, (2000).
Hart, M.C., et al., “Vertebrates Have Conserved Capping Protein alpha Isoforms With Specific Expression Patterns,” Cell Motility and the Cytoskeleton, 38:120-132, (1997).
Yang, X., et al., “Identification of two novel cellular genes associated with multistage carcinogenesis of human . . . ,” Carcinogenesis, 17:563-567, (1996).
Lee, J-W., et al., “Differential Display and Cloning of Messenger RNA from Human Normal Nasal Epithelial Cells Versus . . . ,” Chinese J. Microbiol. Immunol. 29:225-231, (1996).
Cheng Qing
Hui Kam Man
Aeder Sean E
Dann Dorfman Herrell & Skillman P.C.
Rigaut Kathleen D.
Singapore Health Services Pte, Ltd
Yu Misook
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