Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Metal containing – e.g. – chromoproteins – ferritin,...
Reexamination Certificate
2007-01-16
2007-01-16
Weber, Jon (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Metal containing, e.g., chromoproteins, ferritin,...
C530S355000, C514S002600, C424S493000, C424S498000
Reexamination Certificate
active
11237160
ABSTRACT:
A highly magnetically aligned metallothionein (MT) containing manganese (Mn) and cadmium (Cd) has been synthesized. The metallotionein has a formula of MnxCd7−xMT with x being in the range of 1 to 6. Its size and biological functions are similar as those of the native metallothionein as tested by dynamic light scattering, UV, and CD spectroscopic experimental methods. Its maximum magnetic moment per formula unit, in saturation field, is estimated to be 19.46 μB, and persists from 277 to 330 K.
REFERENCES:
patent: 5672687 (1997-09-01), Hermentin et al.
patent: 6262306 (2001-07-01), Leriche et al.
patent: 2002-260907 (2002-09-01), None
Chang et al. (2006) Mn, Cd-metallothionein-2: a room temperature magnetic protein. Biochem. Biophys. Res. Commun. vol. 340, No. 4, pp. 1134-1138.
Ejnik et al. (1999) Interprotein metal ion exchange between cadmium-carbonic anhydrase and apo- or zinc-metallothionein. J. Biol. Inorg. Chem. vol. 4, No. 6, pp. 784-790.
Palumaa et al. (2005) Metal binding of metallothionein-3 versus metallothionein-2: lower affinity and higher plasticity. Biochim. Biophys. Acta. vol. 1747, issue 2, pp. 205-211.
Vasak, M. (1991) Metal removal and substitution in vertebrate and invertebrate metallothiothioneins. Methods Enzymol. vol. 205, pp. 452-458.
Kamilla et al. (2002) New semiconductor materials for magnetoelectronics at room temperature, Bull. Mater. Sci., vol. 25, No. 6, pp. 541-543.
Y. L. Liu et al., Reversible folding of cysteine-rich metallothionein by an over critical reaction path,Biochem. Biophy Res. Comm., vol. 306 pp. 59-63 (2003).
J. D. Otvos et al., Structure of the metal clusters in rabbit live metallothionein,Proc. Natl. Acad. Sci., vol. 77, No. 12 pp. 7094-7098 (1980).
Y Boulanger et al., Model for mammalian metallothionein structure,Proc. Natl. Acad. Sci., vol. 80, pp. 1501-1505 (1983).
Nicola Spaldin, Magnetic materials: Fundamentals and device applications,Cambridge University Press, (2003).
C.C. Chang et al., Semi-empirical simulation of Zn/Cd binding site preference in the metal binding domains of mammalian metallothionein,Protein Engineering, vol. 9, No. 12 pp. 1165-1172 (1996).
A. H. Robbins et al., Refined Crystal Structure of Cd, Zn Metallothionein at 2.0 A Resolution,J. Mol. Biol. vol. 221, pp. 1269-1293 (1991).
D. L. Eaton, Short Communications: Effects of Various Trace Metals on the Binding of Cadmium to Rat hepatic Metallothionein Determined by the Cd/Hemoglobin Affinity Assay,Toxicol. Appl. Pharmacol.vol. 78, pp. 158-162 (1985).
S. Wei et al., Alloy-Stabilized Semiconducting and Magnetic zinc-Blende Phase of MnTe,Phys. Rev. Lett., vol. 56 No. 22, pp. 2391-2394 (1986).
B. Messerle et al., Comparison of the Solution Conformations of Human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 usng Nuclear Magnetic Resonance Spectroscopy,J. Mol. Biol., vol. 225 pp. 433-443 (1992).
W. Prellier et al., Oxide-diluted magnetic semiconductors: a review of the experimental status,J. Phys.: Condensed Matter, vol. 15 pp. R1583-R1601 (2003).
B. Lunn et al., Multiple quantum well structures containing the dilute magnetic semiconductor Cd1-xMnxTe grown by molecular beam epitaxy on InSb, Semicond. Sci. Technol. vol. 5, pp. 1155-1160 (1990).
M. de Naurois et al., High resolution x-ray diffraction studies of short-period CdTe/MnTe superlattices, J. Appl. Phys. vol. 81, pp. 6120-6125 (1997).
S.N. Khanna et al., Quantum Phenomena in Clusters an Nanostructures, ISBN:3-540-00015-1.
Petty, Bryce & Bloor, Introduction to molecular electronics, molecular magnets, London: Edward Arnold, ISBN:0340580097(1995).
O. Kahn, Magnetism of the heteropolymetallic systems,Struct Bonding(Berlin) vol. 68, pp. 89-167 (1987).
Chang Chia-Ching
Kan Lou-Sing
Lee Shang-Fan
Sun Ken-Wen
Academia Sinica
Cohen & Pontani, Lieberman & Pavane
Liu Samuel W.
Weber Jon
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