Molecular lymphatic mapping of sentinel lymph nodes

Details Molecular lymphatic mapping of sentinel lymph nodes Molecular lymphatic mapping of sentinel lymph nodes

2011-03-01

2011-03-01

Strzelecka, Teresa (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C536S023500, C536S024330, C536S025300

Reexamination Certificate

active

07897336

ABSTRACT:
The present invention describes a method for identification and labeling of sentinel lymph nodes (SLNs) and the presence or absence of lymph node metastases as an important diagnostic and prognostic factor in early stage cancers of all types. The method, know as Molecular Lymphatic Mapping, uses traditional dye/radioactive tracer based techniques in conjunction with a nucleic acid marker to identify and label the SLN, not only for current diagnostic methods, but for archival purposes. In addition, MLM can be used to deliver a therapeutic gene or genes to the SLN to activate tumor immunity to tumor cells, and/or to inhibit tumor metastases. The methods may be combined with therapeutic intervention including chemotherapy and radiotherapy.

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